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synovial hyperplasia by impacting osteoclasts. (B) The overexpression of the ERRγ, as regulators of IL-6, VEGFA, and MMPs, will inevitably result in the dysfunction of molecular substances, disrupt homeostasis, and induce osteophyte, synovitis, and cartilage degradation. ERRγ also restrains chondrocyte proliferation by upregulating

synovial fluid across the joint, serve as shock absorbers, and increase the surface area of the tibiofemoral articulation, distributing contact force and reducing the risk of injury throughout the arc of motion.1,12 The menisci enlarge and deepen the contact area between the femur and the tibia