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25. Osteonecrosis of the femoral head
circulation then causes increased intraosseous pressure, ischemic episodes, venous obstruction, and ultimately bone death.5 Following infarct and necrosis of the femoral head, bone resorption and repair occur, leading to loss of structural integrity, collapse, and subchondral failure.3,4 In this chapter, we discuss the different
6. Cancer and metastatic disease
circulating tumor cells to attach and regenerate, a process known as metastatic bone disease (MBD). Postmortem studies confirm that most patients with malignancy have evidence of MBD on autopsy.19 The proximal portion of the long bones, the pelvis, and spine have a rich capillary network
8. Hormonal influences on joint health and osteoarthritis
time of writing this chapter, the most recent studies examining this subject to our knowledge date from the 1990s. A case-control study including 413 White females showed there was increased risk of hip OA in patients who had undergone bilateral surgical oophorectomy.60 Schouten
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